Regulation of Gene Editing Activity Directed by Single-Stranded Oligonucleotides and CRISPR/Cas9 Systems

Single-stranded DNA oligonucleotides (ssODNs) can direct the repair of a single base mutation in human genes. While the regulation of this gene editing reaction has been partially elucidated, the low frequency with which repair occurs has hampered development toward clinical application. In this wor...

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Detalles Bibliográficos
Autores principales: Bialk, Pawel, Rivera-Torres, Natalia, Strouse, Bryan, Kmiec, Eric B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459703/
https://www.ncbi.nlm.nih.gov/pubmed/26053390
http://dx.doi.org/10.1371/journal.pone.0129308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459703/
https://www.ncbi.nlm.nih.gov/pubmed/26053390
http://dx.doi.org/10.1371/journal.pone.0129308

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