Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter

Segmented negative-strand RNA virus (sNSV) polymerases transcribe and replicate the viral RNA (vRNA) within a ribonucleoprotein particle (RNP). We present cryo-EM and X-ray structures of, respectively, apo- and vRNA bound La Crosse orthobunyavirus (LACV) polymerase that give atomic-resolution insigh...

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Detalles Bibliográficos
Autores principales: Gerlach, Piotr, Malet, Hélène, Cusack, Stephen, Reguera, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459711/
https://www.ncbi.nlm.nih.gov/pubmed/26004069
http://dx.doi.org/10.1016/j.cell.2015.05.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459711/
https://www.ncbi.nlm.nih.gov/pubmed/26004069
http://dx.doi.org/10.1016/j.cell.2015.05.006

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