A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development

Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for development. We show that the transcriptional program of hPGCs is distinct from that in mice, with co-expression of somatic specifiers and naive pluripotency genes TFCP2L1 and KLF4. This unique gene regulatory network,...

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Detalles Bibliográficos
Autores principales: Tang, Walfred W.C., Dietmann, Sabine, Irie, Naoko, Leitch, Harry G., Floros, Vasileios I., Bradshaw, Charles R., Hackett, Jamie A., Chinnery, Patrick F., Surani, M. Azim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459712/
https://www.ncbi.nlm.nih.gov/pubmed/26046444
http://dx.doi.org/10.1016/j.cell.2015.04.053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459712/
https://www.ncbi.nlm.nih.gov/pubmed/26046444
http://dx.doi.org/10.1016/j.cell.2015.04.053

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