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DICER1 regulated let-7 expression levels in p53-induced cancer repression requires cyclin D1

Let-7 miRNAs act as tumour suppressors by directly binding to the 3′UTRs of downstream gene products. The regulatory role of let-7 in downstream gene expression has gained much interest in the cancer research community, as it controls multiple biological functions and determines cell fates. For exam...

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Detalles Bibliográficos
Autores principales: Sun, Xin, Tang, Shou-Ching, Xu, Chongwen, Wang, Chenguang, Qin, Sida, Du, Ning, Liu, Jian, Zhang, Yiwen, Li, Xiang, Luo, Gang, Zhou, Jie, Xu, Fei, Ren, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459849/
https://www.ncbi.nlm.nih.gov/pubmed/25702703
http://dx.doi.org/10.1111/jcmm.12522