A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase

The TERT-CLPTM1L region of chromosome 5p15.33 is a multi-cancer susceptibility locus that encodes the reverse transcriptase subunit, hTERT, of the telomerase enzyme. Numerous cancer-associated single-nucleotide polymorphisms (SNPs), including rs10069690, have been identified within the hTERT gene. T...

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Detalles Bibliográficos
Autores principales: Killedar, Anagha, Stutz, Michael D., Sobinoff, Alexander P., Tomlinson, Christopher G., Bryan, Tracy M., Beesley, Jonathan, Chenevix-Trench, Georgia, Reddel, Roger R., Pickett, Hilda A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459975/
https://www.ncbi.nlm.nih.gov/pubmed/26053551
http://dx.doi.org/10.1371/journal.pgen.1005286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459975/
https://www.ncbi.nlm.nih.gov/pubmed/26053551
http://dx.doi.org/10.1371/journal.pgen.1005286

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