Erbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates Kras(G12D)-induced skin tumorigenesis

SAG/RBX2 is the RING (really interesting new gene) component of Cullin-RING ligase, which is required for its activity. An organ-specific role of SAG in tumorigenesis is unknown. We recently showed that Sag/Rbx2, upon lung-targeted deletion, suppressed Kras(G12D)-induced tumorigenesis via inactivati...

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Detalles Bibliográficos
Autores principales: Xie, Chuan-Ming, Wei, Dongping, Zhao, Lili, Marchetto, Sylvie, Mei, Lin, Borg, Jean-Paul, Sun, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460146/
https://www.ncbi.nlm.nih.gov/pubmed/26056141
http://dx.doi.org/10.1083/jcb.201411104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460146/
https://www.ncbi.nlm.nih.gov/pubmed/26056141
http://dx.doi.org/10.1083/jcb.201411104

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