Designing and Testing of Novel Taxanes to Probe the Highly Complex Mechanisms by Which Taxanes Bind to Microtubules and Cause Cytotoxicity to Cancer Cells

Our previous work identified an intermediate binding site for taxanes in the microtubule nanopore. The goal of this study was to test derivatives of paclitaxel designed to bind to this intermediate site differentially depending on the isotype of β-tubulin. Since β-tubulin isotypes have tissue-depend...

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Detalles Bibliográficos
Autores principales: St. George, Marc, Ayoub, Ahmed T., Banerjee, Asok, Churchill, Cassandra D. M., Winter, Philip, Klobukowski, Mariusz, Cass, Carol E., Ludueña, Richard F., Tuszynski, Jack A., Damaraju, Sambasivarao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460180/
https://www.ncbi.nlm.nih.gov/pubmed/26052950
http://dx.doi.org/10.1371/journal.pone.0129168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460180/
https://www.ncbi.nlm.nih.gov/pubmed/26052950
http://dx.doi.org/10.1371/journal.pone.0129168

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