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Bootstrap Restricted Likelihood Ratio Test for the Detection of Rare Variants
In this paper the detection of rare variants association with continuous phenotypes of interest is investigated via the likelihood-ratio based variance component test under the framework of linear mixed models. The hypothesis testing is challenging and nonstandard, since under the null the variance...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Bentham Science Publishers
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460223/ https://www.ncbi.nlm.nih.gov/pubmed/26069459 http://dx.doi.org/10.2174/1389202916666150304234203 |