Cooperative base pair melting by helicase and polymerase positioned one nucleotide from each other

Leading strand DNA synthesis requires functional coupling between replicative helicase and DNA polymerase (DNAP) enzymes, but the structural and mechanistic basis of coupling is poorly understood. This study defines the precise positions of T7 helicase and T7 DNAP at the replication fork junction wi...

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Detalles Bibliográficos
Autores principales: Nandakumar, Divya, Pandey, Manjula, Patel, Smita S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460406/
https://www.ncbi.nlm.nih.gov/pubmed/25970034
http://dx.doi.org/10.7554/eLife.06562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460406/
https://www.ncbi.nlm.nih.gov/pubmed/25970034
http://dx.doi.org/10.7554/eLife.06562

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