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Structural investigations of T854A mutation in EGFR and identification of novel inhibitors using structure activity relationships

BACKGROUND: The epidermal growth factor receptor (EGFR) is a member of the ErbB family that is involved in a number of processes responsible for cancer development and progression such as angiogenesis, apoptosis, cell proliferation and metastatic spread. Malfunction in activation of protein tyrosine...

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Detalles Bibliográficos
Autores principales:	Goyal, Sukriti, Jamal, Salma, Shanker, Asheesh, Grover, Abhinav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460657/ https://www.ncbi.nlm.nih.gov/pubmed/26041145 http://dx.doi.org/10.1186/1471-2164-16-S5-S8

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