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Identification of genomic features in the classification of loss- and gain-of-function mutation

BACKGROUND: Alterations of a genome can lead to changes in protein functions. Through these genetic mutations, a protein can lose its native function (loss-of-function, LoF), or it can confer a new function (gain-of-function, GoF). However, when a mutation occurs, it is difficult to determine whethe...

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Detalles Bibliográficos
Autores principales: Jung, Seunghwan, Lee, Sejoon, Kim, Sangwoo, Nam, Hojung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460711/
https://www.ncbi.nlm.nih.gov/pubmed/26043747
http://dx.doi.org/10.1186/1472-6947-15-S1-S6