Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus

The acute neurotoxicity of oligomeric forms of amyloid-β 1-42 (Aβ) is implicated in the pathogenesis of Alzheimer’s disease (AD). However, how these oligomers might first impair neuronal function at the onset of pathology is poorly understood. Here we have examined the underlying toxic effects cause...

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Detalles Bibliográficos
Autores principales: Whitcomb, Daniel J., Hogg, Ellen L., Regan, Philip, Piers, Thomas, Narayan, Priyanka, Whitehead, Garry, Winters, Bryony L., Kim, Dong-Hyun, Kim, Eunjoon, St George-Hyslop, Peter, Klenerman, David, Collingridge, Graham L., Jo, Jihoon, Cho, Kwangwook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460729/
https://www.ncbi.nlm.nih.gov/pubmed/26055072
http://dx.doi.org/10.1038/srep10934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460729/
https://www.ncbi.nlm.nih.gov/pubmed/26055072
http://dx.doi.org/10.1038/srep10934

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