Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells

Neuroblastoma (NBL) is a heterogeneous tumor characterized by a wide range of clinical manifestations. A high tumor cell differentiation grade correlates to a favorable stage and positive outcome. Expression of the hypoxia inducible factors HIF1-α (HIF1A gene) and HIF2-α (EPAS1 gene) and/or hypoxia-...

Descripción completa

Detalles Bibliográficos
Autores principales: Cimmino, Flora, Pezone, Lucia, Avitabile, Marianna, Acierno, Giovanni, Andolfo, Immacolata, Capasso, Mario, Iolascon, Achille
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460899/
https://www.ncbi.nlm.nih.gov/pubmed/26057707
http://dx.doi.org/10.1038/srep11158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460899/
https://www.ncbi.nlm.nih.gov/pubmed/26057707
http://dx.doi.org/10.1038/srep11158

Ejemplares similares