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Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells
Neuroblastoma (NBL) is a heterogeneous tumor characterized by a wide range of clinical manifestations. A high tumor cell differentiation grade correlates to a favorable stage and positive outcome. Expression of the hypoxia inducible factors HIF1-α (HIF1A gene) and HIF2-α (EPAS1 gene) and/or hypoxia-...
Autores principales: | Cimmino, Flora, Pezone, Lucia, Avitabile, Marianna, Acierno, Giovanni, Andolfo, Immacolata, Capasso, Mario, Iolascon, Achille |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460899/ https://www.ncbi.nlm.nih.gov/pubmed/26057707 http://dx.doi.org/10.1038/srep11158 |
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