Folic acid inhibits COLO-205 colon cancer cell proliferation through activating the FRα/c-SRC/ERK1/2/NFκB/TP53 pathway: in vitro and in vivo studies

To investigate the molecular mechanism underlying folic acid (FA)-induced anti-colon caner activity, we showed that FA caused G0/G1 arrest in COLO-205. FA activated the proto-oncogene tyrosine-protein kinase Src (c-SRC)-mediated signaling pathway to enhance nuclear factor of kappa light polypeptide...

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Detalles Bibliográficos
Autores principales: Kuo, Chun-Ting, Chang, Chieh, Lee, Wen-Sen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460902/
https://www.ncbi.nlm.nih.gov/pubmed/26056802
http://dx.doi.org/10.1038/srep11187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460902/
https://www.ncbi.nlm.nih.gov/pubmed/26056802
http://dx.doi.org/10.1038/srep11187

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