Precision cancer mouse models through genome editing with CRISPR-Cas9

The cancer genome is highly complex, with hundreds of point mutations, translocations, and chromosome gains and losses per tumor. To understand the effects of these alterations, precise models are needed. Traditional approaches to the construction of mouse models are time-consuming and laborious, re...

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Detalles Bibliográficos
Autores principales: Mou, Haiwei, Kennedy, Zachary, Anderson, Daniel G., Yin, Hao, Xue, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460969/
https://www.ncbi.nlm.nih.gov/pubmed/26060510
http://dx.doi.org/10.1186/s13073-015-0178-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460969/
https://www.ncbi.nlm.nih.gov/pubmed/26060510
http://dx.doi.org/10.1186/s13073-015-0178-7

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