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Impaired Expression of Prostaglandin E(2) (PGE(2)) Synthesis and Degradation Enzymes during Differentiation of Immortalized Urothelial Cells from Patients with Interstitial Cystitis/Painful Bladder Syndrome

PURPOSE: The differentiated superficial cells of the urothelium restrict urine flow into the bladder wall. We have demonstrated that urothelial cells isolated from bladders of patients with interstitial cystitis/painful bladder syndrome (IC/PBS) fail to release PGE(2) in response to tryptase. This s...

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Detalles Bibliográficos
Autores principales: Marentette, John O., Hurst, Robert E., McHowat, Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461170/
https://www.ncbi.nlm.nih.gov/pubmed/26057882
http://dx.doi.org/10.1371/journal.pone.0129466