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In Vivo Senescence in the Sbds-Deficient Murine Pancreas: Cell-Type Specific Consequences of Translation Insufficiency
Genetic models of ribosome dysfunction show selective organ failure, highlighting a gap in our understanding of cell-type specific responses to translation insufficiency. Translation defects underlie a growing list of inherited and acquired cancer-predisposition syndromes referred to as ribosomopath...
Autores principales: | Tourlakis, Marina E., Zhang, Siyi, Ball, Heather L., Gandhi, Rikesh, Liu, Hongrui, Zhong, Jian, Yuan, Julie S., Guidos, Cynthia J., Durie, Peter R., Rommens, Johanna M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461263/ https://www.ncbi.nlm.nih.gov/pubmed/26057580 http://dx.doi.org/10.1371/journal.pgen.1005288 |
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