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Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed neutrophils

BACKGROUND: Cytochalasin B does not directly activate the oxygen-radical-producing NADPH oxidase activity of neutrophils but transfers desensitized G-protein coupled receptors (GPCR) into an active signaling state by uncoupling GCPR from the cytoskeleton. The receptor uncoupling results in respirato...

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Detalles Bibliográficos
Autores principales: Bylund, Johan, Pellmé, Sara, Fu, Huamei, Mellqvist, Ulf-Henrik, Hellstrand, Kristoffer, Karlsson, Anna, Dahlgren, Claes
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC446186/
https://www.ncbi.nlm.nih.gov/pubmed/15157285
http://dx.doi.org/10.1186/1471-2121-5-21