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Characterization of Francisella tularensis Schu S4 defined mutants as live-attenuated vaccine candidates

Francisella tularensis (Ft), the etiological agent of tularemia and a Tier 1 select agent, has been previously weaponized and remains a high priority for vaccine development. Ft tularensis (type A) and Ft holarctica (type B) cause most human disease. We selected six attenuating genes from the live v...

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Detalles Bibliográficos
Autores principales: Santiago, Araceli E., Mann, Barbara J., Qin, Aiping, Cunningham, Aimee L., Cole, Leah E., Grassel, Christen, Vogel, Stefanie N., Levine, Myron M., Barry, Eileen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462183/
https://www.ncbi.nlm.nih.gov/pubmed/25986219
http://dx.doi.org/10.1093/femspd/ftv036