Pyrrole-imidazole polyamide targeted to break fusion sites in TMPRSS2 and ERG gene fusion represses prostate tumor growth

Aberrant overexpression of ERG induced by the TMPRSS2-ERG gene fusion is likely involved in the development of prostate cancer. Synthetic pyrrole–imidazole (PI) polyamides recognize and attach to the minor groove of DNA with high affinity and specificity. In the present study, we designed a PI polya...

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Detalles Bibliográficos
Autores principales: Obinata, Daisuke, Ito, Akiko, Fujiwara, Kyoko, Takayama, Ken-Ichi, Ashikari, Daisaku, Murata, Yasutaka, Yamaguchi, Kenya, Urano, Tomohiko, Fujimura, Tetsuya, Fukuda, Noboru, Soma, Masayoshi, Watanabe, Takayoshi, Nagase, Hiroki, Inoue, Satoshi, Takahashi, Satoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462350/
https://www.ncbi.nlm.nih.gov/pubmed/25088707
http://dx.doi.org/10.1111/cas.12493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462350/
https://www.ncbi.nlm.nih.gov/pubmed/25088707
http://dx.doi.org/10.1111/cas.12493

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