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Pyrrole-imidazole polyamide targeted to break fusion sites in TMPRSS2 and ERG gene fusion represses prostate tumor growth
Aberrant overexpression of ERG induced by the TMPRSS2-ERG gene fusion is likely involved in the development of prostate cancer. Synthetic pyrrole–imidazole (PI) polyamides recognize and attach to the minor groove of DNA with high affinity and specificity. In the present study, we designed a PI polya...
Autores principales: | Obinata, Daisuke, Ito, Akiko, Fujiwara, Kyoko, Takayama, Ken-Ichi, Ashikari, Daisaku, Murata, Yasutaka, Yamaguchi, Kenya, Urano, Tomohiko, Fujimura, Tetsuya, Fukuda, Noboru, Soma, Masayoshi, Watanabe, Takayoshi, Nagase, Hiroki, Inoue, Satoshi, Takahashi, Satoru |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462350/ https://www.ncbi.nlm.nih.gov/pubmed/25088707 http://dx.doi.org/10.1111/cas.12493 |
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