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The Atypical Occurrence of Two Biotin Protein Ligases in Francisella novicida Is Due to Distinct Roles in Virulence and Biotin Metabolism
The physiological function of biotin requires biotin protein ligase activity in order to attach the coenzyme to its cognate proteins, which are enzymes involved in central metabolism. The model intracellular pathogen Francisella novicida is unusual in that it encodes two putative biotin protein liga...
Autores principales: | Feng, Youjun, Chin, Chui-Yoke, Chakravartty, Vandana, Gao, Rongsui, Crispell, Emily K., Weiss, David S., Cronan, John E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Microbiology
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462617/ https://www.ncbi.nlm.nih.gov/pubmed/26060274 http://dx.doi.org/10.1128/mBio.00591-15 |
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