The ribosome quality control pathway can access nascent polypeptides stalled at the Sec61 translocon

Cytosolic ribosomes that stall during translation are split into subunits, and nascent polypeptides trapped in the 60S subunit are ubiquitinated by the ribosome quality control (RQC) pathway. Whether the RQC pathway can also target stalls during cotranslational translocation into the ER is not known...

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Detalles Bibliográficos
Autores principales: von der Malsburg, Karina, Shao, Sichen, Hegde, Ramanujan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462936/
https://www.ncbi.nlm.nih.gov/pubmed/25877867
http://dx.doi.org/10.1091/mbc.E15-01-0040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462936/
https://www.ncbi.nlm.nih.gov/pubmed/25877867
http://dx.doi.org/10.1091/mbc.E15-01-0040

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