Structural Insights into the Neutralization Properties of the Fully Human, Anti-interferon Monoclonal Antibody Sifalimumab

We report the three-dimensional structure of human interferon α-2A (IFN-α2A) bound to the Fab fragment of a therapeutic monoclonal antibody (sifalimumab; IgG1/κ). The structure of the corresponding complex was solved at a resolution of 3.0 Å using molecular replacement and constitutes the first repo...

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Detalles Bibliográficos
Autores principales: Oganesyan, Vaheh, Peng, Li, Woods, Robert M., Wu, Herren, Dall'Acqua, William F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463443/
https://www.ncbi.nlm.nih.gov/pubmed/25925951
http://dx.doi.org/10.1074/jbc.M115.652156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463443/
https://www.ncbi.nlm.nih.gov/pubmed/25925951
http://dx.doi.org/10.1074/jbc.M115.652156

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