Cargando…

Insights on Structural Characteristics and Ligand Binding Mechanisms of CDK2

Cyclin-dependent kinase 2 (CDK2) is a crucial regulator of the eukaryotic cell cycle. However it is well established that monomeric CDK2 lacks regulatory activity, which needs to be aroused by its positive regulators, cyclins E and A, or be phosphorylated on the catalytic segment. Interestingly, the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Yan, Zhang, Jingxiao, Gao, Weimin, Zhang, Lilei, Pan, Yanqiu, Zhang, Shuwei, Wang, Yonghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463590/ https://www.ncbi.nlm.nih.gov/pubmed/25918937 http://dx.doi.org/10.3390/ijms16059314

Ejemplares similares

Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae
por: Zhang, Jingxiao, et al.
Publicado: (2015)

Systems Pharmacology Dissection of Multi-Scale Mechanisms of Action for Herbal Medicines in Stroke Treatment and Prevention
por: Zhang, Jingxiao, et al.
Publicado: (2014)

Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor
por: Dai, Shuyan, et al.
Publicado: (2022)

Deciphering the binding behavior of flavonoids to the cyclin dependent kinase 6/cyclin D complex
por: Zhang, Jingxiao, et al.
Publicado: (2018)

Structural Insights into the Ligand-Binding and -Releasing Mechanism of Helicoverpa armigera Pheromone-Binding Protein PBP1
por: Zheng, Jiangge, et al.
Publicado: (2022)

Computational Analysis of Residue-Specific Binding Free Energies of Androgen Receptor to Ligands
por: Shao, Guangfeng, et al.
Publicado: (2021)

Flavonoids as CDK1 Inhibitors: Insights in Their Binding Orientations and Structure-Activity Relationship
por: Navarro-Retamal, Carlos, et al.
Publicado: (2016)

Structural and Functional Insights into Endoglin Ligand Recognition and Binding
por: Alt, Aaron, et al.
Publicado: (2012)

Structural insights into translation regulation by the THF-II riboswitch
por: Xu, Lilei, et al.
Publicado: (2023)

Insights into Ligand–Protein Binding from Local Mechanical Response
por: Patel, Jagdish Suresh, et al.
Publicado: (2011)

Structural insights into the functional diversity of the CDK–cyclin family
por: Wood, Daniel J., et al.
Publicado: (2018)

Insights into integrin-ligand binding and activation from the first crystal structure
por: Humphries, Martin J
Publicado: (2002)

Mechanisms of ligand binding
por: Di Cera, Enrico
Publicado: (2020)

Computational Insights into the Dynamic Structural Features and Binding Characteristics of Recombinase UvsX Compared with RecA
por: Pan, Yue, et al.
Publicado: (2023)

Metal-Free Carbon Quantum Dots Implant Graphitic Carbon Nitride: Enhanced Photocatalytic Dye Wastewater Purification with Simultaneous Hydrogen Production
por: Zhang, Lilei, et al.
Publicado: (2020)

Structural insights into choline-O-sulfatase reveal the molecular determinants for ligand binding
por: Gavira, Jose Antonio, et al.
Publicado: (2022)

Structural basis of the ligand binding and signaling mechanism of melatonin receptors
por: Wang, Qinggong, et al.
Publicado: (2022)

Crystal structures of Bbp from Staphylococcus aureus reveal the ligand binding mechanism with Fibrinogen α
por: Zhang, Xinyue, et al.
Publicado: (2015)

Structural basis of ligand binding modes of human EAAT2
por: Zhang, Zhenglai, et al.
Publicado: (2022)

Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism
por: Wang, Jia, et al.
Publicado: (2020)

Structural Analysis of ABC-family Periplasmic Zinc Binding Protein Provides New Insights Into Mechanism of Ligand Uptake and Release
por: Chandra, Beeram Ravi, et al.
Publicado: (2007)

Insights into the Mechanism of Ligand Binding to Octopine Dehydrogenase from Pecten maximus by NMR and Crystallography
por: Smits, Sander H. J., et al.
Publicado: (2010)

Ligand-binding characteristics of feline insulin-binding immunoglobulin G
por: SUZUKI, Takafumi, et al.
Publicado: (2015)

Structure dictates the mechanism of ligand recognition in the histidine and maltose binding proteins
por: Jayanthi, Lakshmi P., et al.
Publicado: (2020)

Search for β(2) Adrenergic Receptor Ligands by Virtual Screening via Grid Computing and Investigation of Binding Modes by Docking and Molecular Dynamics Simulations
por: Bai, Qifeng, et al.
Publicado: (2014)

Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2
por: Pan, Xin, et al.
Publicado: (2023)

Binding selectivity-dependent molecular mechanism of inhibitors towards CDK2 and CDK6 investigated by multiple short molecular dynamics and free energy landscapes
por: Wang, Lifei, et al.
Publicado: (2022)

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines
por: Coxon, Christopher R., et al.
Publicado: (2016)

Insights into the molecular evolution of oxytocin receptor ligand binding
por: Koehbach, Johannes, et al.
Publicado: (2013)

Mechanistic insight into ligand binding to G-quadruplex DNA
por: Di Leva, Francesco Saverio, et al.
Publicado: (2014)

Insights from Binding on Quadruplex Selective Carbazole Ligands
por: Müller, Diana, et al.
Publicado: (2021)

Targeting CDK1 in cancer: mechanisms and implications
por: Wang, Qiushi, et al.
Publicado: (2023)

Computational Analysis of Structure-Based Interactions for Novel H(1)-Antihistamines
por: Yang, Yinfeng, et al.
Publicado: (2016)

Structural insights into ligand recognition and selectivity of somatostatin receptors
por: Zhao, Wenli, et al.
Publicado: (2022)

Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding
por: Suzuki, Shota, et al.
Publicado: (2023)

Autonomic Neuromodulation for Preventing and Treating Ventricular Arrhythmias
por: Lai, Yanqiu, et al.
Publicado: (2019)

Modeling and Insights into the Structural Characteristics of Chemical Mitochondrial Toxicity
por: Zhang, Ruiqiu, et al.
Publicado: (2023)

Crystal structure of E. coli arginyl-tRNA synthetase and ligand binding studies revealed key residues in arginine recognition
por: Bi, Kelei, et al.
Publicado: (2014)

Insights into intercellular receptor-ligand binding kinetics in cell communication
por: An, Chenyi, et al.
Publicado: (2022)

Ligands and Receptors with Broad Binding Capabilities Have Common Structural Characteristics: An Antibiotic Design Perspective
por: Abrusán, György, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5uaiinf740rgeqlsetnbntfpf9