A Fusion Protein of RGD4C and β-Lactamase Has a Favorable Targeting Effect in Its Use in Antibody Directed Enzyme Prodrug Therapy

Antibody directed enzyme prodrug therapy (ADEPT) utilizing β-lactamase is a promising treatment strategy to enhance the therapeutic effect and safety of cytotoxic agents. In this method, a conjugate (antibody-β-lactamase fusion protein) is employed to precisely activate nontoxic cephalosporin prodru...

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Detalles Bibliográficos
Autores principales: Wang, Hao, Zhou, Xiao-Liang, Long, Wei, Liu, Jin-Jian, Fan, Fei-Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463609/
https://www.ncbi.nlm.nih.gov/pubmed/25927583
http://dx.doi.org/10.3390/ijms16059625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463609/
https://www.ncbi.nlm.nih.gov/pubmed/25927583
http://dx.doi.org/10.3390/ijms16059625

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