Intratracheal instillation of pravastatin for the treatment of murine allergic asthma: a lung-targeted approach to deliver statins

Systemic treatment with statins mitigates allergic airway inflammation, T(H)2 cytokine production, epithelial mucus production, and airway hyperreactivity (AHR) in murine models of asthma. We hypothesized that pravastatin delivered intratracheally would be quantifiable in lung tissues using mass spe...

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Detalles Bibliográficos
Autores principales: Zeki, Amir A, Bratt, Jennifer M, Chang, Kevin Y, Franzi, Lisa M, Ott, Sean, Silveria, Mark, Fiehn, Oliver, Last, Jerold A, Kenyon, Nicholas J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463814/
https://www.ncbi.nlm.nih.gov/pubmed/25969462
http://dx.doi.org/10.14814/phy2.12352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463814/
https://www.ncbi.nlm.nih.gov/pubmed/25969462
http://dx.doi.org/10.14814/phy2.12352

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