Enhanced expression of epithelial sodium channels causes salt-induced hypertension in mice through inhibition of the α(2)-isoform of Na(+), K(+)-ATPase

Knockout of the Nedd4-2 gene in mice results in overexpression of epithelial sodium channels (ENaC) on the plasma membrane in the kidney, choroid plexus and brain nuclei. These mice exhibit enhanced pressor responses to CSF [Na(+)] as well as dietary salt-induced hypertension which both can be block...

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Detalles Bibliográficos
Autores principales: Leenen, Frans H H, Hou, Xiaohong, Wang, Hong-Wei, Ahmad, Monir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463818/
https://www.ncbi.nlm.nih.gov/pubmed/25991719
http://dx.doi.org/10.14814/phy2.12383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463818/
https://www.ncbi.nlm.nih.gov/pubmed/25991719
http://dx.doi.org/10.14814/phy2.12383

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