Cargando…

De-novo design, synthesis and evaluation of novel 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as HIV-1 reverse transcriptase inhibitors

BACKGROUND: Acquired Immune Deficiency Syndrome (AIDS) is the advanced stage of infection caused by Human Immunodeficiency Virus (HIV). HIV/AIDS had a great impact on society, both as an illness and as a source of discrimination. Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) are structura...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chander, Subhash, Ashok, Penta, Singh, Anupam, Murugesan, Sankaranarayanan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463983/ https://www.ncbi.nlm.nih.gov/pubmed/26075019 http://dx.doi.org/10.1186/s13065-015-0111-6

Ejemplares similares

6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers
por: Braconi, Laura, et al.
Publicado: (2020)

Diastereoselective Synthesis of (–)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid via Morpholinone Derivatives
por: Chrzanowska, Maria, et al.
Publicado: (2023)

Medicinal chemistry perspectives of 1,2,3,4-tetrahydroisoquinoline analogs – biological activities and SAR studies
por: Faheem,, et al.
Publicado: (2021)

Orthorhombic polymorph of (6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methanol
por: Elkhamlichi, Aouicha, et al.
Publicado: (2011)

(1S,3S)-Methyl 6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
por: Naicker, Tricia, et al.
Publicado: (2011)

(±)-Ethyl 6,7-dimethoxy-1-(1H-pyrrol-2-yl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylate
por: Nikolova, Rosica Petrova, et al.
Publicado: (2008)

(1S,3S)-Methyl 2-benzyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
por: Naicker, Tricia, et al.
Publicado: (2011)

{(1R,3S)-2-Benzyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl}diphenylmethanol
por: Naicker, Tricia, et al.
Publicado: (2010)

(1R,3S)-Methyl 2-benzyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
por: Naicker, Tricia, et al.
Publicado: (2009)

[(1R,3S)-6,7-Dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol 2.33-hydrate
por: Chakka, Sai Kumar, et al.
Publicado: (2011)

(1R,3S)-N-Benzhydryl-2-benzyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carbothioamide
por: Naicker, Tricia, et al.
Publicado: (2011)

(1R,3S)-Methyl 6,7-dimethoxy-1-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
por: Naicker, Tricia, et al.
Publicado: (2010)

2-[(1R,3S)-6,7-Dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-phenyl-1,3-thiazole
por: Pawar, Sunayna, et al.
Publicado: (2011)

Design and synthesis of tetrahydrophthalimide derivatives as inhibitors of HIV-1 reverse transcriptase
por: Penta, Ashok, et al.
Publicado: (2013)

Correction: Design and synthesis of tetrahydrophthalimide derivatives as inhibitors of HIV-1 reverse transcriptase
por: Penta, Ashok, et al.
Publicado: (2013)

6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid attenuates heptatocellular carcinoma in rats with NMR-based metabolic perturbations
por: Kumar, Pranesh, et al.
Publicado: (2017)

1,2,3,4-Tetrahydroisoquinoline-2-sulfonamide
por: Bouasla, Radia, et al.
Publicado: (2008)

Synthesis and Contractile Activity of Substituted 1,2,3,4-Tetrahydroisoquinolines
por: Ivanov, Iliyan, et al.
Publicado: (2011)

6,7-Dimethoxy-1,4-anthraquinone
por: Kitamura, Chitoshi, et al.
Publicado: (2008)

Crystal structure of [(2S)-1-[(3S)-3-carboxy-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl]-1-oxopropan-2-yl][(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]azanium chloride acetonitrile monosolvate
por: Li, Ai-zhen, et al.
Publicado: (2014)

Biological evaluation and structure activity relationship of 9-methyl-1-phenyl-9H-pyrido[3,4-b]indole derivatives as anti-leishmanial agents
por: Ashok, Penta, et al.
Publicado: (2019)

Practical and Efficient Synthesis of α-Aminophosphonic Acids Containing 1,2,3,4-Tetrahydroquinoline or 1,2,3,4-Tetrahydroisoquinoline Heterocycles
por: Ordóñez, Mario, et al.
Publicado: (2016)

CKD-712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Inhibits the NF-κB Activation and Augments Akt Activation during TLR4 Signaling
por: Lee, Jeonggi, et al.
Publicado: (2011)

1-(2-Fluorophenyl)-6,7-dimethoxyisochroman
por: Saeed, Aamer, et al.
Publicado: (2009)

2-(2-Iodophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile
por: Ma, Yanni, et al.
Publicado: (2011)

2-(4-Iodophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile
por: Ma, Yanni, et al.
Publicado: (2011)

(S)-N-Benzyl-2-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
por: Naicker, Tricia, et al.
Publicado: (2010)

Crystal structure of 2-methyl-1,2,3,4-tetrahydroisoquinoline trihydrate
por: Langenohl, Felix, et al.
Publicado: (2020)

4-Chloro-N-methyl-2-(1,2,3,4-tetrahydroisoquinolin-1-yl)aniline
por: Harrad, Mohamed Anouar, et al.
Publicado: (2010)

1-Methyl-1,2,3,4-tetrahydroisoquinoline, an Endogenous Neuroprotectant and MAO Inhibitor with Antidepressant-Like Properties in the Rat
por: Wąsik, Agnieszka, et al.
Publicado: (2013)

Crystal structure of 3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-1-one
por: Caracelli, Ignez, et al.
Publicado: (2015)

Synthesis of 1-(para-methoxyphenyl)tetrazolyl-Substituted 1,2,3,4-Tetrahydroisoquinolines and Their Transformations Involving Activated Alkynes
por: Titov, Alexander A., et al.
Publicado: (2018)

(S)-Benzyl 3-phenylcarbamoyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate
por: Naicker, Tricia, et al.
Publicado: (2012)

2-Methyl-1,2,3,4-tetrahydroisoquinolin-6-yl N-phenylcarbamate
por: Zhang, Qi-Hong, et al.
Publicado: (2009)

6-Amino-2-methyl-8-phenyl-1,2,3,4-tetrahydroisoquinoline-5,7-dicarbonitrile
por: Wang, Dao-Cai, et al.
Publicado: (2013)

1-Cyclohexyl-6,7-dimethoxy-1,4-dihydronaphthalene
por: Chen, Shao-Yuan, et al.
Publicado: (2014)

Ethyl 4-methyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylate
por: Li, Xing-Yao, et al.
Publicado: (2012)

(S)-4-Phenyl-2-(1,2,3,4-tetrahydroisoquinolin-3-yl)-1,3-thiazole
por: Pawar, Sunayna, et al.
Publicado: (2011)

N-(Adamantan-1-yl)-1,2,3,4-tetrahydroisoquinoline-2-carbothioamide
por: El-Emam, Ali A., et al.
Publicado: (2013)

1-Methyl-1,2,3,4-Tetrahydroisoquinoline, an Endogenous Amine with Unexpected Mechanism of Action: New Vistas of Therapeutic Application
por: Antkiewicz-Michaluk, Lucyna, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_oa56jh7r7uk4ldnc032saj8d8p