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Single-molecule modeling of mRNA degradation by miRNA: Lessons from data

Recent experimental results on the effect of miRNA on the decay of its target mRNA have been analyzed against a previously hypothesized single molecule degradation pathway. According to that hypothesis, the silencing complex (miRISC) first interacts with its target mRNA and then recruits the protein...

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Detalles Bibliográficos
Autores principales: Sin, Celine, Chiarugi, Davide, Valleriani, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464216/
https://www.ncbi.nlm.nih.gov/pubmed/26050661
http://dx.doi.org/10.1186/1752-0509-9-S3-S2