Orthogonal dual-modification of proteins for the engineering of multivalent protein scaffolds

To add new tools to the repertoire of protein-based multivalent scaffold design, we have developed a novel dual-labeling strategy for proteins that combines residue-specific incorporation of unnatural amino acids with chemical oxidative aldehyde formation at the N-terminus of a protein. Our approach...

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Detalles Bibliográficos
Autores principales: Mühlberg, Michaela, Hoesl, Michael G, Kuehne, Christian, Dernedde, Jens, Budisa, Nediljko, Hackenberger, Christian P R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2015
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464295/
https://www.ncbi.nlm.nih.gov/pubmed/26124880
http://dx.doi.org/10.3762/bjoc.11.88

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464295/
https://www.ncbi.nlm.nih.gov/pubmed/26124880
http://dx.doi.org/10.3762/bjoc.11.88

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