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Influence of length and flexibility of spacers on the binding affinity of divalent ligands

We present a quantitative model for the binding of divalent ligand–receptor systems. We study the influence of length and flexibility of the spacers on the overall binding affinity and derive general rules for the optimal ligand design. To this end, we first compare different polymeric models and de...

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Detalles Bibliográficos
Autores principales: Liese, Susanne, Netz, Roland R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464470/
https://www.ncbi.nlm.nih.gov/pubmed/26124882
http://dx.doi.org/10.3762/bjoc.11.90