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Influence of length and flexibility of spacers on the binding affinity of divalent ligands
We present a quantitative model for the binding of divalent ligand–receptor systems. We study the influence of length and flexibility of the spacers on the overall binding affinity and derive general rules for the optimal ligand design. To this end, we first compare different polymeric models and de...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464470/ https://www.ncbi.nlm.nih.gov/pubmed/26124882 http://dx.doi.org/10.3762/bjoc.11.90 |