EGFR tyrosine kinase targeted compounds: in vitro antitumor activity and molecular modeling studies of new benzothiazole and pyrimido[2,1-b]benzothiazole derivatives

In this study, we illustrate computer aided drug design of new benzothiazole and pyrimido[2,1-b]benzothiazole derivatives as epidermal growth factor receptor tyrosine kinase (EGFR-TK) inhibitors. Compounds 1-5 were screened at NCI, USA, for antitumor activity against non-small cell lung cancer (NCI-...

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Detalles Bibliográficos
Autores principales: Gabr, Moustafa T., El-Gohary, Nadia S, El-Bendary, Eman R., El-Kerdawy, Mohamed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464492/
https://www.ncbi.nlm.nih.gov/pubmed/26417284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464492/
https://www.ncbi.nlm.nih.gov/pubmed/26417284

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