Iridium-Catalyzed Arylative Cyclization of Alkynones by 1,4-Iridium Migration**

1,4-Metal migrations enable the remote functionalization of C—H bonds, and have been utilized in a wide variety of valuable synthetic methods. The vast majority of existing examples involve the 1,4-migration of palladium or rhodium. Herein, the stereoselective synthesis of complex polycycles by the...

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Detalles Bibliográficos
Autores principales: Partridge, Benjamin M, Solana González, Jorge, Lam, Hon Wai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464530/
https://www.ncbi.nlm.nih.gov/pubmed/24842318
http://dx.doi.org/10.1002/anie.201403271
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author Partridge, Benjamin M
Solana González, Jorge
Lam, Hon Wai
author_facet Partridge, Benjamin M
Solana González, Jorge
Lam, Hon Wai
author_sort Partridge, Benjamin M
collection PubMed
description 1,4-Metal migrations enable the remote functionalization of C—H bonds, and have been utilized in a wide variety of valuable synthetic methods. The vast majority of existing examples involve the 1,4-migration of palladium or rhodium. Herein, the stereoselective synthesis of complex polycycles by the iridium-catalyzed arylative cyclization of alkynones with arylboronic acids is described. To our knowledge, these reactions involve the first reported examples of 1,4-iridium migration.
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spelling pubmed-44645302015-06-17 Iridium-Catalyzed Arylative Cyclization of Alkynones by 1,4-Iridium Migration** Partridge, Benjamin M Solana González, Jorge Lam, Hon Wai Angew Chem Int Ed Engl Communications 1,4-Metal migrations enable the remote functionalization of C—H bonds, and have been utilized in a wide variety of valuable synthetic methods. The vast majority of existing examples involve the 1,4-migration of palladium or rhodium. Herein, the stereoselective synthesis of complex polycycles by the iridium-catalyzed arylative cyclization of alkynones with arylboronic acids is described. To our knowledge, these reactions involve the first reported examples of 1,4-iridium migration. WILEY-VCH Verlag 2014-06-16 2014-05-19 /pmc/articles/PMC4464530/ /pubmed/24842318 http://dx.doi.org/10.1002/anie.201403271 Text en © 2014 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Partridge, Benjamin M
Solana González, Jorge
Lam, Hon Wai
Iridium-Catalyzed Arylative Cyclization of Alkynones by 1,4-Iridium Migration**
title Iridium-Catalyzed Arylative Cyclization of Alkynones by 1,4-Iridium Migration**
title_full Iridium-Catalyzed Arylative Cyclization of Alkynones by 1,4-Iridium Migration**
title_fullStr Iridium-Catalyzed Arylative Cyclization of Alkynones by 1,4-Iridium Migration**
title_full_unstemmed Iridium-Catalyzed Arylative Cyclization of Alkynones by 1,4-Iridium Migration**
title_short Iridium-Catalyzed Arylative Cyclization of Alkynones by 1,4-Iridium Migration**
title_sort iridium-catalyzed arylative cyclization of alkynones by 1,4-iridium migration**
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464530/
https://www.ncbi.nlm.nih.gov/pubmed/24842318
http://dx.doi.org/10.1002/anie.201403271
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AT solanagonzalezjorge iridiumcatalyzedarylativecyclizationofalkynonesby14iridiummigration
AT lamhonwai iridiumcatalyzedarylativecyclizationofalkynonesby14iridiummigration

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