“Invisible” Conformers of an Antifungal Disulfide Protein Revealed by Constrained Cold and Heat Unfolding, CEST-NMR Experiments, and Molecular Dynamics Calculations

Transition between conformational states in proteins is being recognized as a possible key factor of function. In support of this, hidden dynamic NMR structures were detected in several cases up to populations of a few percent. Here, we show by two- and three-state analysis of thermal unfolding, tha...

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Detalles Bibliográficos
Autores principales: Fizil, Ádám, Gáspári, Zoltán, Barna, Terézia, Marx, Florentine, Batta, Gyula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464532/
https://www.ncbi.nlm.nih.gov/pubmed/25676351
http://dx.doi.org/10.1002/chem.201404879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464532/
https://www.ncbi.nlm.nih.gov/pubmed/25676351
http://dx.doi.org/10.1002/chem.201404879

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