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Scale-up bioprocess development for production of the antibiotic valinomycin in Escherichia coli based on consistent fed-batch cultivations

BACKGROUND: Heterologous production of natural products in Escherichia coli has emerged as an attractive strategy to obtain molecules of interest. Although technically feasible most of them are still constrained to laboratory scale production. Therefore, it is necessary to develop reasonable scale-u...

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Detalles Bibliográficos
Autores principales: Li, Jian, Jaitzig, Jennifer, Lu, Ping, Süssmuth, Roderich D, Neubauer, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464625/
https://www.ncbi.nlm.nih.gov/pubmed/26063334
http://dx.doi.org/10.1186/s12934-015-0272-y