Cardiospecific CD36 suppression by lentivirus-mediated RNA interference prevents cardiac hypertrophy and systolic dysfunction in high-fat-diet induced obese mice

BACKGROUND: Fatty acid (FA) catabolism abnormality has been proved to play an important role in obesity-related cardiomyopathy. We hypothesized that cardiospecific suppression of CD36, the predominant membrane FA transporter, would protect against obesity-related cardiomyopathy. METHODS: Four-wk-old...

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Detalles Bibliográficos
Autores principales: Zhang, Yijie, Bao, Mingwei, Dai, Mingyan, Wang, Xin, He, Wenbo, Tan, Tuantuan, Lin, Dandan, Wang, Wei, Wen, Ying, Zhang, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464858/
https://www.ncbi.nlm.nih.gov/pubmed/26036798
http://dx.doi.org/10.1186/s12933-015-0234-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464858/
https://www.ncbi.nlm.nih.gov/pubmed/26036798
http://dx.doi.org/10.1186/s12933-015-0234-z

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