The Basic Helix-Loop-Helix Transcription Factor E47 Reprograms Human Pancreatic Cancer Cells to a Quiescent Acinar State With Reduced Tumorigenic Potential

OBJECTIVES: Pancreatic ductal adenocarcinoma (PDA) initiates from quiescent acinar cells that attain a Kras mutation, lose signaling from basic helix-loop-helix (bHLH) transcription factors, undergo acinar-ductal metaplasia, and rapidly acquire increased growth potential. We queried whether PDA cell...

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Detalles Bibliográficos
Autores principales: Kim, SangWun, Lahmy, Reyhaneh, Riha, Chelsea, Yang, Challeng, Jakubison, Brad L., van Niekerk, Jaco, Staub, Claudio, Wu, Yifan, Gates, Keith, Dong, Duc Si, Konieczny, Stephen F., Itkin-Ansari, Pamela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464938/
https://www.ncbi.nlm.nih.gov/pubmed/25894862
http://dx.doi.org/10.1097/MPA.0000000000000328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464938/
https://www.ncbi.nlm.nih.gov/pubmed/25894862
http://dx.doi.org/10.1097/MPA.0000000000000328

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