Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells

Chromosomal deletions associated with human diseases, such as cancer are common, but synteny issues complicate modeling of these deletions in mice. We use cellular reprogramming and genome engineering to functionally dissect the loss of chromosome 7q [del(7q)], a somatic cytogenetic abnormality pres...

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Detalles Bibliográficos
Autores principales: Kotini, Andriana G, Chang, Chan-Jung, Boussaad, Ibrahim, Delrow, Jeffrey J, Dolezal, Emily K, Nagulapally, Abhinav B, Perna, Fabiana, Fishbein, Gregory A, Klimek, Virginia M, Hawkins, R David, Huangfu, Danwei, Murry, Charles E, Graubert, Timothy, Nimer, Stephen D, Papapetrou, Eirini P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464949/
https://www.ncbi.nlm.nih.gov/pubmed/25798938
http://dx.doi.org/10.1038/nbt.3178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464949/
https://www.ncbi.nlm.nih.gov/pubmed/25798938
http://dx.doi.org/10.1038/nbt.3178

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