Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection

Neutrophil elastase (NE) and cathepsin G (CG) contribute to intracellular microbial killing but, if left unchecked and released extracellularly, promotes tissue damage. Conversely, mechanisms that constrain neutrophil serine protease activity protect against tissue damage but may have the untoward e...

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Detalles Bibliográficos
Autores principales: Zhao, Yani, Olonisakin, Tolani F., Xiong, Zeyu, Hulver, Mei, Sayeed, Sameera, Yu, Min Ting, Gregory, Alyssa D., Kochman, Elizabeth J., Chen, Bill B., Mallampalli, Rama K., Sun, Ming, Silverstein, Roy L., Stolz, Donna B., Shapiro, Steve D., Ray, Anuradha, Ray, Prabir, Lee, Janet S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465063/
https://www.ncbi.nlm.nih.gov/pubmed/25492474
http://dx.doi.org/10.1038/mi.2014.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465063/
https://www.ncbi.nlm.nih.gov/pubmed/25492474
http://dx.doi.org/10.1038/mi.2014.120

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