Inhibition of ERBB2-overexpressing Tumors by Recombinant Human Prolidase and Its Enzymatically Inactive Mutant

ERBB2 is an oncogenic receptor tyrosine kinase overexpressed in a subset of human breast cancer and other cancers. We recently found that human prolidase (PEPD), a dipeptidase, is a high affinity ERBB2 ligand and cross-links two ERBB2 monomers. Here, we show that recombinant human PEPD (rhPEPD) stro...

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Detalles Bibliográficos
Autores principales: Yang, Lu, Li, Yun, Bhattacharya, Arup, Zhang, Yuesheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465122/
https://www.ncbi.nlm.nih.gov/pubmed/26086037
http://dx.doi.org/10.1016/j.ebiom.2015.03.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465122/
https://www.ncbi.nlm.nih.gov/pubmed/26086037
http://dx.doi.org/10.1016/j.ebiom.2015.03.016

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