Ligand regulation of a constitutively dimeric EGF receptor

Ligand-induced receptor dimerization has traditionally been viewed as the key event in transmembrane signalling by epidermal growth factor receptors (EGFRs). Here we show that the Caenorhabditis elegans EGFR orthologue LET-23 is constitutively dimeric, yet responds to its ligand LIN-3 without changi...

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Detalles Bibliográficos
Autores principales: Freed, Daniel M., Alvarado, Diego, Lemmon, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465127/
https://www.ncbi.nlm.nih.gov/pubmed/26060020
http://dx.doi.org/10.1038/ncomms8380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465127/
https://www.ncbi.nlm.nih.gov/pubmed/26060020
http://dx.doi.org/10.1038/ncomms8380

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