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Ligand regulation of a constitutively dimeric EGF receptor
Ligand-induced receptor dimerization has traditionally been viewed as the key event in transmembrane signalling by epidermal growth factor receptors (EGFRs). Here we show that the Caenorhabditis elegans EGFR orthologue LET-23 is constitutively dimeric, yet responds to its ligand LIN-3 without changi...
Autores principales: | Freed, Daniel M., Alvarado, Diego, Lemmon, Mark A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465127/ https://www.ncbi.nlm.nih.gov/pubmed/26060020 http://dx.doi.org/10.1038/ncomms8380 |
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