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Enantioselective synthesis of tertiary α-chloro esters by non-covalent catalysis
We report an enantioselective approach to tertiary α-chloro esters through the reaction of silyl ketene acetals and N-chlorosuccinimide. The reaction is promoted by a chiral squaramide catalyst, which is proposed to engage both reagents exclusively through non-covalent interactions. Application of t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465138/ https://www.ncbi.nlm.nih.gov/pubmed/26085694 http://dx.doi.org/10.1016/j.tetlet.2015.01.124 |