Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase

BACKGROUND: Morphine and fentanyl are opioid analgesics in wide clinical use that act through the μ-opioid receptor (MOR). However, one limitation of their long-term effectiveness is the development of tolerance. Receptor desensitization has been proposed as a putative mechanism driving tolerance to...

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Detalles Bibliográficos
Autores principales: Marcus, David J., Zee, Michael, Hughes, Alex, Yuill, Matthew B., Hohmann, Andrea G., Mackie, Ken, Guindon, Josée, Morgan, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465461/
https://www.ncbi.nlm.nih.gov/pubmed/26065412
http://dx.doi.org/10.1186/s12990-015-0031-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465461/
https://www.ncbi.nlm.nih.gov/pubmed/26065412
http://dx.doi.org/10.1186/s12990-015-0031-4

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