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Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase

BACKGROUND: Morphine and fentanyl are opioid analgesics in wide clinical use that act through the μ-opioid receptor (MOR). However, one limitation of their long-term effectiveness is the development of tolerance. Receptor desensitization has been proposed as a putative mechanism driving tolerance to...

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Detalles Bibliográficos
Autores principales:	Marcus, David J., Zee, Michael, Hughes, Alex, Yuill, Matthew B., Hohmann, Andrea G., Mackie, Ken, Guindon, Josée, Morgan, Daniel J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465461/ https://www.ncbi.nlm.nih.gov/pubmed/26065412 http://dx.doi.org/10.1186/s12990-015-0031-4

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