Two-Stage Priming of Allogeneic Natural Killer Cells for the Treatment of Patients with Acute Myeloid Leukemia: A Phase I Trial

Human Natural Killer (NK) cells require at least two signals to trigger tumor cell lysis. Absence of ligands providing either signal 1 or 2 provides NK resistance. We manufactured a lysate of a tumour cell line which provides signal 1 to resting NK cells without signal 2. The tumor-primed NK cells (...

Descripción completa

Detalles Bibliográficos
Autores principales: Kottaridis, Panagiotis D., North, Janet, Tsirogianni, Maria, Marden, Chloe, Samuel, Edward R., Jide-Banwo, Sam, Grace, Sarah, Lowdell, Mark W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465629/
https://www.ncbi.nlm.nih.gov/pubmed/26062124
http://dx.doi.org/10.1371/journal.pone.0123416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465629/
https://www.ncbi.nlm.nih.gov/pubmed/26062124
http://dx.doi.org/10.1371/journal.pone.0123416

Ejemplares similares