Cargando…
Two-Stage Priming of Allogeneic Natural Killer Cells for the Treatment of Patients with Acute Myeloid Leukemia: A Phase I Trial
Human Natural Killer (NK) cells require at least two signals to trigger tumor cell lysis. Absence of ligands providing either signal 1 or 2 provides NK resistance. We manufactured a lysate of a tumour cell line which provides signal 1 to resting NK cells without signal 2. The tumor-primed NK cells (...
Autores principales: | Kottaridis, Panagiotis D., North, Janet, Tsirogianni, Maria, Marden, Chloe, Samuel, Edward R., Jide-Banwo, Sam, Grace, Sarah, Lowdell, Mark W. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465629/ https://www.ncbi.nlm.nih.gov/pubmed/26062124 http://dx.doi.org/10.1371/journal.pone.0123416 |
Ejemplares similares
-
Predictors of recovery following allogeneic CD34+-selected cell infusion without conditioning to correct poor graft function
por: Cuadrado, Maria M., et al.
Publicado: (2019) -
Phase I non-randomized clinical trial of allogeneic natural killer cells infusion in acute myeloid leukemia patients
por: Ahmadvand, Mohammad, et al.
Publicado: (2023) -
Tumor- and cytokine-primed human natural killer cells exhibit distinct phenotypic and transcriptional signatures
por: Sabry, May, et al.
Publicado: (2019) -
Natural Killer Immunotherapy for Minimal Residual Disease Eradication Following Allogeneic Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia
por: Hattori, Norimichi, et al.
Publicado: (2019) -
A Killer Disarmed: Natural Killer Cell Impairment in Myelodysplastic Syndrome
por: Arellano-Ballestero, Helena, et al.
Publicado: (2023)